Operating in modern day London, the Hellsing Organization's mission is to cleanse England of the new manuafactured vampires. However, the main assasin of this organization just happens to be a vampire himself - his name is Alucard, who serves no one but the organization's young leader, the iron-willed woman Sir Integra Wingates Hellsing, as well as Alucard's new protege, a young police girl turned draculina named Seras Victoria

Lately, a rash of artificially-created vampires has taken the organization by surprise. As it turns out, a neo-Nazi society known as the Millennium Order is responsible for creating these vampires. Their sole purpose... to achieve what Nazi Germany couldn't do over 60 years ago with human soldiers... the total conquest of the world!